Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid Conditions
Relevance. COVID-19 vaccination reduces mortality and the course of severe diseases. However, there is an insufficiency of studies evaluating factors leading to infection among COVID-19 vaccinated individuals. Aim. Identification of epidemiological features that distinguish cases of the disease in v...
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Published in | Èpidemiologiâ i vakcinoprofilaktika (Online) Vol. 22; no. 6; pp. 133 - 138 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English Russian |
Published |
Numikom LLC
06.01.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Relevance.
COVID-19 vaccination reduces mortality and the course of severe diseases. However, there is an insufficiency of studies evaluating factors leading to infection among COVID-19 vaccinated individuals.
Aim.
Identification of epidemiological features that distinguish cases of the disease in vaccinated and unvaccinated cohorts.
Materials and methods.
The analysis of the incidence of COVID-19 in 1126 hospitalized patients in the period from 23.06.2021 to 01.05.2022 was carried out taking into account the presence or absence of vaccination against the SARS-CoV-2 virus.
Results.
It was found that the risk of COVID-19 getting sick in the unimmunized was 1.5 times higher than in the vaccinated (p < 0.05). The incidence of hospitalization, due to the severity of the condition (moderate, severe and extremely severe), in unvaccinated people with no history of comorbidities, is more than 3 times higher than in vaccinated people (p < 0.05) in the same group. The probability of death from COVID-19 among vaccinated people is 1.5 times lower than among unimmunized people (p < 0.05). The age characteristic of mortality in vaccinated people shifts to the «senile» age (76.93 ± 1.32), while among the unimmunized, the age of death is closer to the category of «elderly» (73.74 ± 1.39 years) (p ≤ 0.05). In the structure of mortality among the vaccinated, the main share was made up of patients with a history of 3 to 7 concomitant systemic diseases (66.7%), while among the unvaccinated, the main share (74.5%) were patients either without comorbidities or with a history of 1 to 2 concomitant diseases.
Conclusion.
The results of the epidemiological features of the COVID-2 epidemic process have shown that vaccination against the SARS-CoV-2 virus is vital for elderly and senile people with comorbid conditions. |
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ISSN: | 2073-3046 2619-0494 |
DOI: | 10.31631/2073-3046-2023-22-6-133-138 |