Comparative Analysis of Fecal Short Chain Fatty Acids Profiles in Atopic Dermatitis And Healthy Infants

Rationale Short chain fatty acids (SCFAs) are intermediate and end products of metabolism of dietary fibre by intestinal commensal bacteria, and regulate the host’s immune function. Longitudinal multivariate analysis was employed to study the dynamic trends of SCFAs, while adjusted for possible conf...

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Published inJournal of allergy and clinical immunology Vol. 141; no. 2; p. AB131
Main Authors Huy Ta, Le Duc, Yip Chan, James Chun, Huang, Chiung-Hui, Yap, Gaik Chin, Shek, Lynette Pei-Chi, Goh, Anne, Van Bever, Hugo P.S., Teoh, Oon Hoe, Soh, Jian Yi, Thomas, Biju, Ramamurthy, Mahesh Babu, Goh, Daniel, Lay, Christophe, Soh, Shu E., Yap, Fabian, Tan, Kok Hian, Chong, Yap-Seng, Godfrey, Keith B.M., Gluckman, Peter D., Chan, Eric Chun Yong, Lee, Bee Wah
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2018
Elsevier Limited
Subjects
Antibiotics
Atopic dermatitis
Comparative analysis
Dermatitis
Eczema
Family medical history
Fatty acids
Feces
Infants
Multivariate analysis
Singapore
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Summary:Rationale Short chain fatty acids (SCFAs) are intermediate and end products of metabolism of dietary fibre by intestinal commensal bacteria, and regulate the host’s immune function. Longitudinal multivariate analysis was employed to study the dynamic trends of SCFAs, while adjusted for possible confounders (gender, presence of siblings, mode of delivery, feeding pattern, use of pre-natal antibiotics and family history of atopic diseases).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.417