An unprecedented synthesis of some novel 3,4-fused pyrazolidinone-γ-lactam bicyclic moieties from 2,3-dioxo-4-carboxy-5-(subtituted)pyrrolidines
A new pathway for the synthesis of novel 3,4-fused pyrazolidinone-γ-lactam (4) starting from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines (1) was developed. The key synthetic strategy involved hydrazonation of the precursor 1 followed by subsequent reduction reaction of the enamino ester 2 and in...
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| Published in | Organic communications Vol. 12; no. 3; pp. 121 - 131 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Gebze
ACG Publications
01.09.2019
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| Subjects | |
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| Abstract | A new pathway for the synthesis of novel 3,4-fused pyrazolidinone-γ-lactam (4) starting from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines (1) was developed. The key synthetic strategy involved hydrazonation of the precursor 1 followed by subsequent reduction reaction of the enamino ester 2 and intramolecular cyclization reaction to furnish the unprecedented 3,4-fused pyrazolidinone-γ- lactam (4) in reasonable yield. The structures of all synthesized compounds were confirmed by spectroscopic methods and chemical transformation. |
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| AbstractList | A new pathway for the synthesis of novel 3,4-fused pyrazolidinone-γ-lactam (4) starting from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines (1) was developed. The key synthetic strategy involved hydrazonation of the precursor 1 followed by subsequent reduction reaction of the enamino ester 2 and intramolecular cyclization reaction to furnish the unprecedented 3,4-fused pyrazolidinone-γ- lactam (4) in reasonable yield. The structures of all synthesized compounds were confirmed by spectroscopic methods and chemical transformation. |
| Author | Mohamma, Mohd Fazli t Hamzah, hmad Sazali Shaamer, Zurina i Abdul Rashid, Fatin Nur Ain |
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| Snippet | A new pathway for the synthesis of novel 3,4-fused pyrazolidinone-γ-lactam (4) starting from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines (1) was developed.... |
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| Title | An unprecedented synthesis of some novel 3,4-fused pyrazolidinone-γ-lactam bicyclic moieties from 2,3-dioxo-4-carboxy-5-(subtituted)pyrrolidines |
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