An unprecedented synthesis of some novel 3,4-fused pyrazolidinone-γ-lactam bicyclic moieties from 2,3-dioxo-4-carboxy-5-(subtituted)pyrrolidines

A new pathway for the synthesis of novel 3,4-fused pyrazolidinone-γ-lactam (4) starting from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines (1) was developed. The key synthetic strategy involved hydrazonation of the precursor 1 followed by subsequent reduction reaction of the enamino ester 2 and in...

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Published inOrganic communications Vol. 12; no. 3; pp. 121 - 131
Main Authors Abdul Rashid, Fatin Nur Ain, Mohamma, Mohd Fazli t, Shaamer, Zurina i, Hamzah, hmad Sazali
Format Journal Article
LanguageEnglish
Published Gebze ACG Publications 01.09.2019
Subjects
Amides
Chemical reduction
Organic chemistry
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Summary:A new pathway for the synthesis of novel 3,4-fused pyrazolidinone-γ-lactam (4) starting from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines (1) was developed. The key synthetic strategy involved hydrazonation of the precursor 1 followed by subsequent reduction reaction of the enamino ester 2 and intramolecular cyclization reaction to furnish the unprecedented 3,4-fused pyrazolidinone-γ- lactam (4) in reasonable yield. The structures of all synthesized compounds were confirmed by spectroscopic methods and chemical transformation.
ISSN:1307-6175
1307-6175
DOI:10.25135/acg.oc.62.19.07.1323