Formulation and Evaluation of Sustained Release Matrix Tablet of Metformin Hydrochloride

Attempt was to formulate the oral sustained release metformin hydrochloride matrix tablets by using hydroxypropyl methylcellulose of (HPMC K-50 M).The tablets were prepared by wet granulation technique. The granules were evaluated for angle of repose, loose bulk density, tapped and bulk density. It...

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Bibliographic Details
Published inJournal of Current Pharma Research Vol. 8; no. 3; pp. 2403 - 2412
Main Authors Deshmukh, M T, Kore, V U, Kshirsagar, P K, Jagtap, S V, Shete, R V
Format Journal Article
LanguageEnglish
Published Karad Human Journals 15.05.2018
Subjects
Angle of repose
Antidiabetics
Bulk density
Controlled release
Dissolution
Drug delivery systems
Drugs
Formulations
Friability
Granulation
Metformin
Methylcellulose
Sustained release
Tablets
Japan
Mumbai India
India
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Summary:Attempt was to formulate the oral sustained release metformin hydrochloride matrix tablets by using hydroxypropyl methylcellulose of (HPMC K-50 M).The tablets were prepared by wet granulation technique. The granules were evaluated for angle of repose, loose bulk density, tapped and bulk density. It shows satisfactory results. The tablets were subjected to thickness, weight variation, drug content, hardness, friability, and in-vitro release studies. In-vitro dissolution profiles of the all formulations were studied in 0.1 N HCl for first 2 hours then 6.8 pH phosphate buffer for next 10 hours using USP dissolution apparatus II (paddle) apparatus. FTIR spectral studies showed that there was no interaction between the drug and excipients. In development of Metformin HCl sustained release tablets was a good approach to sustain the release rate to overcome frequent administration and also to release the drug for a prolong time.
ISSN:2230-7834
2230-7842
DOI:10.33786/JCPR.2018.v08i03.003