Assessment of the Anti-cancer Effects of Camel Milk Exosomes (CMEXOs) on Murine Colorectal Cancer Cell Line (CT-26)

• Published in: Iranian journal of allergy, asthma, and immunology
• Main Authors: Karbasi, Samira, Erfanian, Nafiseh, Dehghan, Hamideh, Zarban, Asghar, Namaei, Mohammad Hasan, Hanafi-Bojd, Mohammad Yahya, Nasseri, Saeed
• Format: Journal Article
• Language: English
• Published: 05.06.2024
• ISSN: 1735-1502; 1735-5249
• DOI: 10.18502/ijaai.v23i3.15641

Today, camel milk consumption in the Middle East is trendy because it is believed that it reduces the risk of cancer. Recently, studies have discovered that most of milk's beneficial effects are because of its nanoparticles, especially exosomes. The objective of the present research was to investigate the anti-cancer effects of camel milk exosomes (CMEXOs) in the murine colorectal cancer cell line (CT-26). Our findings verified the existence of exosomes measuring approximately 114.1±3.4 nm in diameter. Through MTT and migration assays, we established that CMEXOs exhibit dose-dependent anti-proliferative and anti-migration effects on the CT-26 cell line. Furthermore, our study showed that treatment with CMEXOs led to a reduction in TNF-α and IL-6 gene expression in CT-26 cells. While additional in vivo studies are required, our data demonstrate that CMEXOs have anti-proliferative and anti-migration effects on CT-26, possibly by influencing crucial genes within the inflammation pathway.