The Symptoms and Signs of Upper Airway Resistance Syndrome

• Published in: Chest Vol. 123; no. 1; pp. 87 - 95
• Main Authors: Gold, Avram R., Dipalo, Francis, Gold, Morris S., O'Hearn, Daniel
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2003; American College of Chest Physicians
• Subjects: alpha-delta sleep; bruxism; chronic fatigue syndrome; fibromyalgia; functional somatic syndromes; irritable bowel syndrome; sleep-disordered breathing; temporomandibular joint syndrome; upper airway resistance syndrome; AHI; CPAP; bruxism; upper airway resistance syndrome; irritable bowel syndrome; Pmask; NREM; OSA/H; UARS; functional somatic syndromes; alpha-delta sleep; sleep-disordered breathing; fibromyalgia; temporomandibular joint syndrome; chronic fatigue syndrome; IBS; BMI; CMH
• ISSN: 0012-3692; 1931-3543
• DOI: 10.1378/chest.123.1.87

The functional somatic syndromes are associated with a variety of symptoms/signs of uncertain etiology. We determined the prevalence of several of those symptoms/signs in patients with sleep-disordered breathing and examined the relationship between the prevalence of the symptoms/signs and the severity of sleep-disordered breathing. A descriptive study without intervention. A university sleep-disorders center located in a suburban setting. Three groups of 25 consecutively collected patients with sleep-disordered breathing. Groups varied in their apnea hypopnea indexes (AHIs) as follows: upper airway resistance syndrome (UARS) [AHI < 10/h), mild-to-moderate obstructive sleep apnea/hypopnea (OSA/H) [AHI ≥ 10 to < 40/h), and moderate-to-severe OSA/H (AHI ≥ 40/h). Patients underwent comprehensive medical histories, physical examinations, and full-night polysomnography. The diagnosis of UARS included quantitative measurement of inspiratory airflow and inspiratory effort with demonstration of inspiratory flow limitation. The percentage of women among the patients with sleep-disordered breathing (p = 0.001) and the prevalence of sleep-onset insomnia (p = 0.04), headaches (p = 0.01), irritable bowel syndrome (p = 0.01), and alpha-delta sleep (p = 0.01) was correlated with decreasing severity of AHI group. We conclude that patients with UARS, mild-to-moderate OSA/H and moderate-to-severe OSA/H differ in their presenting symptoms/signs. The symptoms/signs of UARS closely resemble those of the functional somatic syndromes.