Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent Targeting pqs Quorum Sensing

• Published in: Angewandte Chemie Vol. 126; no. 4; pp. 1127 - 1130
• Main Authors: Lu, Cenbin, Maurer, Christine K., Kirsch, Benjamin, Steinbach, Anke, Hartmann, Rolf W.
• Format: Journal Article
• Language: English; German
• Published: Weinheim WILEY-VCH Verlag 20.01.2014; WILEY‐VCH Verlag
• Subjects: Antivirulenz; Inhibitoren; Medizinische Chemie; Resistenz; Wirkstoff-Forschung

The virulence regulator PqsR of Pseudomonas aeruginosa is considered as an attractive target for attenuating the bacterial pathogenicity without eliciting resistance. However, despite efforts and desires, no promising PqsR antagonist has been discovered thus far. Now, a surprising functionality chan...