Clinical efficacy of combined use of physical training and a fixed combination of an angiotensin receptor blocker II - valsartanumand the calcium antagonist - amlodipine on ambulatory (III) stage of rehabilitation in smoking patients with comorbid diseases (coronary heart disease, hypertension and chronic obstructive pulmonary disease)

• Published in: CardioSomatika Vol. 7; no. 2; pp. 29 - 41
• Main Authors: Bubnova, M. G, Sulim, Yu. N, Aronov, D. M, Novikova, N. K, Vygodin, V. A, Meshcheryakova, N. N
• Format: Journal Article
• Language: English
• Published: Concilium Medicum 15.06.2016
• Subjects: a fixed combination of amlodipine/valsartanum; arterial hypertension; chronic obstructive pulmonary disease; ischemic heart disease; physical training
• ISSN: 2221-7185; 2658-5707
• DOI: 10.26442/CS45227

Goal. The study of the clinical efficacy of combined use of systematic physical training (PT) and a fixed combination of a blocker of receptors for angiotensin II (ARB), valsartanum (Val) to dihydropyridine calcium antagonist (AA) with amlodipine (AML), appointed as part of standard therapy for smokers in patients with cardio-pulmonary pathology outpatient (III) stage of rehabilitation. Material. The study included 30 men aged 40 to 65 years. All patients were treated with statins, aspirin, .-blockers, selective and systematic FT performed 3 times a week for 4 months (duration of the training - 60 minutes with a period of moderate intensity training load of 50-60% of the threshold power cycling). After randomization, patients were divided into two groups: Group 1 (n=12) received additional angiotensin converting enzyme inhibitors (ACEI) and 2nd (n=18) - the combined preparation Exforge ® (AML 5-10 mg/Val 60 mg). Study duration - 4 months. Methods. In a study conducted clinical examination, bicycle stress test (VEM-test), echocardiography (echocardiography), ambulatory blood pressure monitoring (ABPM), spirometry, determination of concentrations of lipids and lipoproteins, glucose, fibrinogen, uric acid, creatinine, a calculation of glomerular filtration rate by MDRD. They used questionnaires: Hospital Anxiety and Depression Scale (HADS), St George's Hospital (SGRQ) and quality of life (QOL) SF-36. Results. Against the background of the FT, combined with taking an ACE inhibitor or a fixed combination of AML/Val, reduced the number of smoked cigarettes at 20.8±5.2 pieces (