Cover Picture: Proteolytic Actuation of Nanoparticle Self-Assembly (Angew. Chem. Int. Ed. 19/2006)

Sterically shielded …︁…︁ nanoparticles diffuse freely in solution and biological fluids until proteases expressed by cancer cells trigger them to self‐assemble. In their Communication on page 3161ff., S. N. Bhatia and co‐workers show that complimentary Fe3O4 nanoparticle binding is inhibited by the...

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 45; no. 19; p. 2985
Main Authors Harris, Todd J., von Maltzahn, Geoffrey, Derfus, Austin M., Ruoslahti, Erkki, Bhatia, Sangeeta N.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 05.05.2006
WILEY‐VCH Verlag
Subjects
magnetic properties
nanostructures
proteases
self-assembly
triggered assembly
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Summary:Sterically shielded …︁…︁ nanoparticles diffuse freely in solution and biological fluids until proteases expressed by cancer cells trigger them to self‐assemble. In their Communication on page 3161ff., S. N. Bhatia and co‐workers show that complimentary Fe3O4 nanoparticle binding is inhibited by the attachment of protease‐cleavable polymers. Cleavage of these polymers triggers “latent” nanoparticles to form multimeric assemblies with emergent properties.
Bibliography:istex:8386EBF35BF3CD2C6397D1601CD17AD090C0A9FF
ArticleID:ANIE200690067
ark:/67375/WNG-FKZMN8C7-Z
These authors contributed equally
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200690067