Oral T-cell-rich large B-cell lymphoma in a horse

Lymphoma is the most common tumor of hematopoietic origin in horses. The course of the disease and clinical signs vary greatly, depending on tumor location and extent. The aim of this report is to describe the occurrence of T-cell-rich oral large B-cell lymphoma with marked local infiltration in a 2...

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Published inVeterinary research communications Vol. 48; no. 6; pp. 4067 - 4071
Main Authors Peretti, Jéssica Cristina, dos Santos, Aline Bielak, Davi dos Santos, Ezequiel, Machado, Tanise Policarpo, Pescador, Caroline Argenta, Quillas, Luis Jhordy Alfaro, Milani, Vanessa Marostega, Picetti, Taline Scalco, da Motta, Adriana Costa
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.12.2024
Springer Nature B.V
Subjects
Anorexia
Autopsy
B-cell lymphoma
Biomedical and Life Sciences
Brief Report
CD20 antigen
CD3 antigen
Dyspnea
Life Sciences
Lymphocytes B
Lymphocytes T
Lymphoma
Masseter muscle
Metastases
Neoplasia
Palate
Respiration
Stroma
Tumors
Veterinary Medicine/Veterinary Science
Zoology
Immunohistochemistry
Oral cavity
Equine
Lymphoma
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Summary:Lymphoma is the most common tumor of hematopoietic origin in horses. The course of the disease and clinical signs vary greatly, depending on tumor location and extent. The aim of this report is to describe the occurrence of T-cell-rich oral large B-cell lymphoma with marked local infiltration in a 25-year-old Crioula mare. The mare showed an increase in volume on the right side of its face, dyspnea, anorexia, and progressive weight loss. The clinical assessment showed that the lesion was located in the rostral and caudal sinuses and was markedly invasive to adjacent structures. The autopsy revealed a yellow mass with a soft to firm consistency, infiltrating multiple bones in the skull, and extensively invading the hard palate and masseter muscle. Histologically the mass comprised an undifferentiated malignant neoplasm characterized by a densely cellular neoplasm composed of large CD20 + neoplastic B-lymphocytes admixed with sheets of small, CD3 + reactive T-lymphocytes supported by delicate fibrovascular stroma leading to the diagnosis of oral T-cell-rich large B-cell lymphoma.
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ISSN:0165-7380
1573-7446
1573-7446
DOI:10.1007/s11259-024-10476-z