Human histologic and histomorphometric analysis comparing OsteoGraf/N with PepGen P-15 in the maxillary sinus elevation procedure: a case report

• Published in: Implant dentistry Vol. 9; no. 4; p. 298
• Main Authors: Krauser, J T, Rohrer, M D, Wallace, S S
• Format: Journal Article
• Language: English
• Published: United States 2000
• Subjects: Alveolar Ridge Augmentation - methods; Animals; Atrophy; Bone Matrix - pathology; Bone Matrix - transplantation; Bone Regeneration - physiology; Bone Substitutes - therapeutic use; Bone Transplantation - methods; Bone Transplantation - pathology; Cattle; Cell Adhesion - physiology; Cell Differentiation - physiology; Cell Division - physiology; Cell Movement - physiology; Dental Implantation, Endosseous; Dental Implants; Follow-Up Studies; Humans; Jaw, Edentulous - pathology; Jaw, Edentulous - surgery; Male; Maxilla - pathology; Maxilla - surgery; Maxillary Sinus - pathology; Maxillary Sinus - surgery; Middle Aged; Osteogenesis - physiology
• ISSN: 1056-6163
• DOI: 10.1097/00008505-200009040-00004

The use of the anorganic bovine bone mineral OsteoGraf/N combined with demineralized freeze-dried bone allograft has received widespread use in sinus elevations. This composite graft material has proven to be suitable, predictable, and successful for the placement and integration of endosseous implants in the edentulous, atrophic maxilla. In this case study, the current materials and accepted methodology were compared with the latest tissue-engineered bone replacement graft material, PepGen P-15. PepGen P-15 is a combination of OsteoGraf/N and a synthetic peptide (P-15) that mimics the cell-binding domain of Type-I collagen responsible for cell migration, differentiation, and proliferation. The radiographic, histologic, and histomorphometric evaluations of the sinus grafted with PepGen P-15 showed enhanced bone formation within a shorter time interval compared with the composite graft material of OsteoGraf/N and demineralized freeze-dried bone allograft.