Consensus in acute myeloid leukemia in Mexico

• Published in: Gaceta médica de México Vol. 158; no. M3; pp. M1 - M48
• Main Authors: Arana-Luna, Luara L, Alvarado-Ibarra, Martha, Silva-Michel, Luis G, Morales-Maravilla, Adrián, González-Rubio, María Del C, Chávez-Aguilar, Lénica A, Tena-Iturralde, Ma Fernanda, Mojica-Balceras, Liliana, Zapata-Canto, Nidia, Galindo-Delgado, Patricia, Miranda-Madrazo, Ma Raquel, Morales-Hernández, Alba E, Silva-Vera, Karina, Grimaldo-Gómez, Flavio A, Hernández-Caballero, Álvaro, Bates-Martin, Ramón A, Álvarez-Vera, José L, Tepepa-Flores, Fredy, Teomitzi-Sánchez, Óscar, Fermín-Caminero, Denisse J, Peña-Celaya, José A de la, Salazar-Ramírez, Óscar, Flores-Villegas, Luz V, Guerra-Alarcón, Lidia V, Leyto-Cruz, Faustino, Inclán-Alarcón, Sergio I, Milán-Salvatierra, Andrea I, Ventura-Enríquez, Yanet, Pérez-Lozano, Uendy, Báez-Islas, Pamela E, Tapia-Enríquez, Ana L, Palma-Moreno, Orlando G, Aguilar-Luévano, Jocelyn, Espinosa-Partida, Arturo, Pérez-Jacobo, Luis F, Rojas-Castillejos, Flavio, Ruiz-Contreras, Josué I, Loera-Fragoso, Sergio J, Medina-Coral, Jesús E, Acosta-Maldonado, Brenda L, Soriano-Mercedes, Emely J, Saucedo-Montes, Erick E, Valero-Saldana, Luis M, González-Prieto, Susana G, Nava-Villegas, Lorena, Hernández-Colin, Ana K, Hernández-Alcántara, Areli E, Zárate-Rodríguez, Pedro A, Ignacio-Ibarra, Gregorio, Meillón-García, Luis A, Espinosa-Bautista, Karla A, Cruz, Cindy Ledesma-de la, Barbosa-Loría, Diego M, García-Castillo, Carolina, Balderas-Delgado, Carolina, Cabrera-García, Álvaro, Pérez-Zúñiga, Juan M, Hernández-Ruiz, Eleazar, Villela-Peña, Atenas, Cortés, Sue Cynthia Gómez, Romero-Rodelo, Hilda, Garzón-Velásquez, Katheryn B, Serrano-Hernández, Cristina, Martínez-Ríos, Annel, Pedraza-Solís, Ma Luisa, Martínez-Coronel, Jorge A, Narváez-Davalos, Iris M, García-Camacho, Alinka S, Merino-Pasaye, Laura E, Aguilar-Andrade, Carolina, Aguirre-Domínguez, Juan A, Guzmán-Mera, Pedro G, Rosa, Elizabeth Delgado-de la, López, Perla E Flores, González-Aguirre, Lilia L, Ramírez-Alfaro, Edgar M, Vera-Calderón, Heidi, Meza-Dávalos, Ma Lizeth, Murillo-Cruz, Juan, Pichardo-Cepín, Yayra M, Ramírez-Romero, Eva F
• Format: Journal Article
• Language: English
• Published: Mexico 2022
• Subjects: Cell Differentiation; Consensus; Humans; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - therapy; Mexico; Mexico; Leucemia mieloide aguda; Myeloid blasts; Cytogenetic risk; Acute myeloid leukemia; Riesgo citogenético; Blastos
• ISSN: 0016-3813
• DOI: 10.24875/GMM.M21000598

Acute myeloid leukemia (AML) comprises a heterogeneous group of hematopoietic cell neoplasms of myeloid lineage that arise from the clonal expansion of their precursors in the bone marrow, interfering with cell differentiation, leading to a syndrome of bone marrow failure. AML is a consequence of genetic and epigenetic changes (point mutations, gene rearrangements, deletions, amplifications, and arrangements in epigenetic changes that influence gene expression) in hematopoietic precursor cells, which create a clone of abnormal cells that are capable of proliferating but cannot differentiate into mature hematopoietic cells or undergo programmed cell death. The diagnosis requires more than 20% myeloid blasts in the bone marrow and certain cytogenic abnormalities. Treatment will depend on age, comorbidities, and cytogenetic risk among the most frequent.