The Chemical Degradation of Folic Acid

2,4,7-Trihydroxypteridine is readily accessible from folic acid and other naturally occurring pteridines by way of 2-amino-4-hydroxypteridine-6-carboxylic acid, 2-amino-4-hydroxypteridine, and isoxanthopterin (2-amino-4,7-dihydroxypteridine). After irradiation with ultraviolet light and brief acid h...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 241; no. 2; pp. 379 - 382
Main Authors Shaw, Elliott, Baugh, Charles M., Krumdieck, C.L.
Format Journal Article
LanguageEnglish
Published American Society for Biochemistry and Molecular Biology 25.01.1966
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Summary:2,4,7-Trihydroxypteridine is readily accessible from folic acid and other naturally occurring pteridines by way of 2-amino-4-hydroxypteridine-6-carboxylic acid, 2-amino-4-hydroxypteridine, and isoxanthopterin (2-amino-4,7-dihydroxypteridine). After irradiation with ultraviolet light and brief acid hydrolysis, 2,4,7-trihydroxypteridine gives rise to glyoxylic acid coming from carbon atoms 6 and 7 of the pteridine ring. A detailed method is described suitable for use on a micro scale in the study of the biosynthetic origin of these carbon atoms in pteridines.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)96927-9