IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS

Sixty-nine children (5 to 14 years old) with infectious mononucleosis caused by EBV were observed in acute phase and during recovery period. The indexes under study did evaluate cell-mediated and humoral immunity, levels of spontaneous and mitogen-induced production of IL-2, IL-10, IFNγ by periphera...

Full description

Saved in:
Bibliographic Details
Published inMedit͡s︡inskai͡a︡ immunologii͡a Vol. 9; no. 4-5; pp. 541 - 545
Main Authors Kurtasova, L. M., Golovanova, A. E.
Format Journal Article
LanguageEnglish
Russian
Published St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 17.07.2014
Subjects
cytokines
ifnγ
il-10
il-2
immunity
infectious mononucleosis
Online AccessGet full text

Cover

More Information
Summary:Sixty-nine children (5 to 14 years old) with infectious mononucleosis caused by EBV were observed in acute phase and during recovery period. The indexes under study did evaluate cell-mediated and humoral immunity, levels of spontaneous and mitogen-induced production of IL-2, IL-10, IFNγ by peripheral blood mononuclears. We have founded appropriate changes to be dependent on clinical phase of the disease. The most significant changes were revealed during acute phase of disease. A positive dynamics of cell-mediated and humoral immune response was observed during convalescence period. However, complete normalization of most immunologic indexes and cytokine status did not occur, corresponding to the clinical signs. This situation necessitates immune rehabilitation to be carried out for the children having at this phase of infectious mononucleosis.
ISSN:1563-0625
2313-741X
DOI:10.15789/1563-0625-2007-4-5-541-545