INFLAMMATION ROLE IN FORMATION OF EARLY DISTURBANCES OF A FUNCTIONAL CONDITION OF A LIVER AT COMMUNITY — ACQUIRED PNEUMONIA (LITERATURE REVIEW)

• Published in: Arkhivʺ vnutrenneĭ medit͡s︡iny Vol. 8; no. 5; pp. 361 - 365
• Main Authors: Gorbunov, A. Yu, Bobyleva, H. S., Zelenin, V. A., Suvorova, H. V.
• Format: Journal Article
• Language: English; Russian
• Published: SINAPS LLC 09.10.2018
• Subjects: dysfunction of a liver; succinatecontaining medicines; the community-acquired pneumonia (cap); the endothelium dysfunction
• ISSN: 2226-6704; 2411-6564
• DOI: 10.20514/2226-6704-2018-8-5-361-365

The Community-acquired Pneumonia (CAP) is an urgent problem of modern medicine due to its high incidence, morbidity, the increasing resistance of a microflora to antibacterial therapy, a large number of complications and a high lethality. Now in a pathogenesis of pneumonia the leading value belongs to various changes of metabolism, including an induction of peroxide oxidation of lipids and formation of an oxidizing stress. The importance is attached to violations of a functional condition of a liver at pneumonia which pathogenetic mechanisms of damage are diverse, including with participation of a vascular endothelium. At the same time in realization of therapeutic approaches on a normalization of metabolism of cages of an organism the priority part is assigned to oxidation substrata. It is shown that the succinatecontaining medicines realize various pharmacological effects, providing in general cytoprotective action that allows to consider them as perspective the compositions having hepatoprotective activity which are necessary in complex therapy of the community-acquired Pneumonia (CAP).