A CLINICAL STUDY ON PROSTATE CANCER DIAGNOSIS WITH cDNA MACROARRAY

Objective: To diagnose prostatic cancer (CAP) with cDNA macroarray. Methods: Total RNA was isolated from patients with prostate cancer and from normal people, and poly(A) RNA was further purified. Then differentially expressed genes were analysed in CaP and normal prostate by cDNA macroarray system....

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Published inChinese journal of cancer research Vol. 17; no. 1; pp. 66 - 70
Main Author 钟惟德 刘良式 刘文华 江福能 曾广翘 戴奇山 何慧婵 毕学成 彭志强 谢克基 魏鸿霭
Format Journal Article
LanguageEnglish
Published Department of Urology, the First Municipal People's Hospital, Guangzhou Medical College, Guangzhou 510180%Institute for Life Sciences, Sun Yat-Sen University, Guangzhou 510060 01.03.2005
Subjects
CaP
cDNA
分子机制
前列腺肿瘤
诊断方法
Neoplasm
cDNA macroarray
Prostate
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ISSN1000-9604
1993-0631
DOI10.1007/s11670-005-0014-5

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Summary:Objective: To diagnose prostatic cancer (CAP) with cDNA macroarray. Methods: Total RNA was isolated from patients with prostate cancer and from normal people, and poly(A) RNA was further purified. Then differentially expressed genes were analysed in CaP and normal prostate by cDNA macroarray system. Results: There were differential expressions of nine prostate-associated specific genes in CaP as compared with normal prostate, among which, 7 were significantly up-regulated and 2 were down-regulated. Conclusion: As a diagnostic approach at molecular level, the cDNA macroarray is supposed to elevate the detection rate of CaP.
Bibliography:11-2591/R
R737.25
ISSN:1000-9604
1993-0631
DOI:10.1007/s11670-005-0014-5