Synthesis of 4,5-Dialkyl-2-perfluoroaryl-1H-imidazol-1-ols and 4,5-Dimethyl-2-perfluoroaryl-1H-imidazoles

Aliphatic α-hydroxyamino oximes reacted with perfluoroaromatic aldehydes to give α-perfluoroaryl nitrones which underwent cyclization in acetic acid with the formation of 4,5-dialkyl-2-perfluoroaryl-1 H -imidazol-1-ols. The latter were also obtained directly from aliphatic α-hydroxyamino oximes and...

Full description

Saved in:
Bibliographic Details
Published inRussian journal of organic chemistry Vol. 57; no. 12; pp. 1968 - 1973
Main Authors Os’kina, I. A., Vinogradov, A. S., Selivanov, B. A., Savelyev, V. A., Platonov, V. E., Tikhonov, A. Ya
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2021
Subjects
Chemistry
Chemistry and Materials Science
Organic Chemistry
1
aliphatic α-hydroxyamino oximes
perfluoroaromatic aldehydes
chloroacetone
condensation
imidazoles
1-hydroxy-1
Online AccessGet full text

Cover

More Information
Summary:Aliphatic α-hydroxyamino oximes reacted with perfluoroaromatic aldehydes to give α-perfluoroaryl nitrones which underwent cyclization in acetic acid with the formation of 4,5-dialkyl-2-perfluoroaryl-1 H -imidazol-1-ols. The latter were also obtained directly from aliphatic α-hydroxyamino oximes and perfluoro­aromatic aldehydes in acetic acid without isolation of intermediate nitrones. The reaction of 4,5-dimethyl-2-perfluoroaryl-1 H -imidazol-1-ols with chloroacetone afforded 4,5-dimethyl-2-perfluoroaryl-1 H -imidazoles.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428021120101