A growth-rate composition formula for the growth of E.coli on co-utilized carbon substrates

When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system...

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Bibliographic Details
Published inMolecular systems biology Vol. 11; no. 4; p. 801
Main Authors Hermsen, Rutger, Okano, Hiroyuki, You, Conghui, Werner, Nicole, Hwa, Terence
Format Journal Article
LanguageEnglish
Published England 09.04.2015
Subjects
Algorithms
Carbon - metabolism
Catabolite Repression
Culture Media - metabolism
Cyclic AMP - metabolism
Cyclic AMP Receptor Protein - metabolism
Escherichia coli - drug effects
Escherichia coli - growth & development
Escherichia coli - metabolism
Escherichia coli Proteins - metabolism
Feedback, Physiological
Genes, Reporter
metabolic coordination
catabolite repression
mixed carbon‐substrate growth
bacterial growth
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Summary:When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates are co-utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1744-4292
DOI:10.15252/msb.20145537