The Effect of Methotrexate on the Pool of Low-Molecular Weight Sulfur-Containing Compounds in the Brain of Rats

Single administration of methotrexate at a dose of 0.1 mg/kg on the first and seventh days is associated with an imbalance in the pool of low-molecular weight sulfur-containing compounds whose severity decreases in the following series: hypothalamus > midbrain > cerebral hemispheres > stria...

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Bibliographic Details
Published inNeurochemical journal Vol. 13; no. 2; pp. 176 - 181
Main Authors Novogrodskaya, Ya. I., Kurbat, M. N., Doroshenko, E. M.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.04.2019
Subjects
Biomedical and Life Sciences
Biomedicine
Experimental Articles
Neurosciences
midbrain
striatum
sulfur-containing aminoacids
methotrexate
cerebral hemispheres
hypothalamus
cerebellum
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Summary:Single administration of methotrexate at a dose of 0.1 mg/kg on the first and seventh days is associated with an imbalance in the pool of low-molecular weight sulfur-containing compounds whose severity decreases in the following series: hypothalamus > midbrain > cerebral hemispheres > striatum > cerebellum. In 24 h, homocysteine remethylation in the cerebral hemispheres decreases, transsulfuration activity in the striatum increases, taurine synthesis in the midbrain decreases, homocysteic acid and taurine synthesis in the hypothalamus increases, and, in the cerebellum, the oxidase pathway of cysteine and homocysteine transformation are activated and taurine transsulfuration and biosynthesis is inhibited. At 7 days after a single meth-otrexate administration, the general trend included the inhibition of the oxidation reactions and activation of transsulfuration and decarboxylation in taurine synthesis.
ISSN:1819-7124
1819-7132
DOI:10.1134/S1819712419020090