DVT exclusion in symptomatic outpatients: use of a rapid D-dimer immunofiltration assay and comparison with three enzyme immuno assays

Many authors have shown that plasma measurement of the degradation products of cross-linked fibrin, D-dimer, may be able to identify patients without DVT. Enzyme Immuno assay (EIA) have shown the best performance characteristics with a sensitivity and a negative predictive value around 100%. These t...

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Published inFibrinolysis Vol. 10; pp. 117 - 119
Main Authors Pannocchia, A., Chiappino, I., Valpreda, S., Bazzan, M., Giorgianni, A., Lanfranco, G., Pautasso, F., Rabbia, C., Roglia, D., Aluffi, E.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1996
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Summary:Many authors have shown that plasma measurement of the degradation products of cross-linked fibrin, D-dimer, may be able to identify patients without DVT. Enzyme Immuno assay (EIA) have shown the best performance characteristics with a sensitivity and a negative predictive value around 100%. These tests are time-consuming and therefor non applicable in the rapid exclusion of DVT. The immunofiltration test we have studied showed a good correlation with three EIA tests of known performance characteristics. This test has a sensitivity and predictive negative value comparable to EIA but is more rapid and thus suitable as a rapid exclusion test for DVT.
ISSN:0268-9499
DOI:10.1016/S0268-9499(96)80064-6