An efficient, step-economical synthesis of β-carboline tethered imidazopyrido[3,4-]indoles from acetals
An efficient one-pot pseudo three component cascade annulation reaction has been devised to generate the fluorescent β-carboline tethered imidazopyrido[3,4- b ]indole derivatives. These scaffolds were afforded in high yields via one-pot cascade reaction of diversified β-carboline acetals with NH 4 C...
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Published in | New journal of chemistry Vol. 48; no. 25; pp. 11394 - 1146 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
24.06.2024
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | An efficient one-pot pseudo three component cascade annulation reaction has been devised to generate the fluorescent β-carboline tethered imidazopyrido[3,4-
b
]indole derivatives. These scaffolds were afforded in high yields
via
one-pot cascade reaction of diversified β-carboline acetals with NH
4
Cl through the formation of three C-N bonds in a single operation. The current protocol is step-economical and offers high atom-economy, short reaction time and high structural diversity with excellent yields (57-90%). The synthesized compounds displayed promising photophysical properties and delivered luminescence quantum yield (
Φ
F
) up to 55%.
An efficient one-pot pseudo three component cascade annulation reaction has been devised to generate the fluorescent β-carboline tethered imidazopyrido[3,4-
b
]indole derivatives. |
---|---|
Bibliography: | https://doi.org/10.1039/d4nj01467g Electronic supplementary information (ESI) available. See DOI |
ISSN: | 1144-0546 1369-9261 |
DOI: | 10.1039/d4nj01467g |