Nabyty inhibitor czynnika VIII w przebiegu raka prostaty u 71-letniego mężczyzny – opis przypadku

Acquired hemophilia (AH) is a rare and serious disease mainly affecting elderly patients. It is caused by the production of autoantibodies directed against coagulation factors mainly factor VIII. Patients present spontaneous bleeding: subcutaneous, intramuscular and mucosal. Up to 50% cases of AH re...

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Bibliographic Details
Published inActa haematologica polonica Vol. 44; no. 2; pp. 153 - 155
Main Author Kapelko-Słowik, Katarzyna
Format Journal Article
LanguagePolish
Published Elsevier Sp. z o.o 01.04.2013
Subjects
Acquired hemophilia
Factor VIII inhibitor
inhibitor czynnika VIII
nabyta hemofilia
Prostate cancer
rak prostaty
Acquired hemophilia
Factor VIII inhibitor
inhibitor czynnika VIII
Prostate cancer
rak prostaty
nabyta hemofilia
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Summary:Acquired hemophilia (AH) is a rare and serious disease mainly affecting elderly patients. It is caused by the production of autoantibodies directed against coagulation factors mainly factor VIII. Patients present spontaneous bleeding: subcutaneous, intramuscular and mucosal. Up to 50% cases of AH remain unexplained. Autoimmune disorders, neoplastic diseases, infections and drugs are predisponding factors. Therapy of bleeds included activated prothrombin complex concentrates and activated recombinant factor VII. In most patients with AH immunosuppressive therapy results in elimination of antibody and restoration of factor VIII activity.
ISSN:0001-5814
DOI:10.1016/j.achaem.2013.02.015