Murine and simian retrovirus models: the threshold hypothesis

By considering the dynamic relationship between retroviruses and their hosts, we have developed a unifying hypothesis to explain such disparate clinical phenomena as differential pathogenicity of a given virus in adults and neonates, transient infection with clearance of provirus-containing cells, l...

Full description

Saved in:
Bibliographic Details
Published inAIDS (London) Vol. 10 Suppl A; p. S33
Main Authors Ruprecht, R M, Baba, T W, Rasmussen, R, Hu, Y, Sharma, P L
Format Journal Article
LanguageEnglish
Published England 1996
Subjects
Animals
Disease Models, Animal
Disease Progression
Haplorhini
HIV Infections - physiopathology
HIV-1 - pathogenicity
Humans
Immunity, Cellular
Mice
Models, Biological
Retroviridae
Online AccessGet more information

Cover

More Information
Summary:By considering the dynamic relationship between retroviruses and their hosts, we have developed a unifying hypothesis to explain such disparate clinical phenomena as differential pathogenicity of a given virus in adults and neonates, transient infection with clearance of provirus-containing cells, long-term non-progression and vaccine effects of fully pathogenic viruses. The threshold hypothesis predicts that an opportunity exists during acute retroviral infection to influence the ultimate clinical outcome: if virus replication is kept below threshold by any means, including drug therapy or passive immunoprophylaxis with neutralizing antibodies, the host will prevail and win the race.
ISSN:0269-9370
DOI:10.1097/00002030-199601001-00005