Beyond rheumatic: therapeutic implications in mitral regurgitation

The dominant focus on rheumatic aetiology of mitral regurgitation (MR) often overshadows other causes. This challenges optimal management when the aetiology is non-rheumatic, as exemplified below in an 8-year-old girl, hailing from Uganda, who was diagnosed and managed as rheumatic MR with unusually...

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Published inCardiology in the young p. 1
Main Authors Selvam, Nisanth, Brown, Kelsey, Puello, Yonairy C, Sasikumar, Navaneetha, Wirth, Scott
Format Journal Article
LanguageEnglish
Published England 01.08.2025
Subjects
mitral regurgitation
systemic lupus erythematosus
Rheumatic heart disease
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Summary:The dominant focus on rheumatic aetiology of mitral regurgitation (MR) often overshadows other causes. This challenges optimal management when the aetiology is non-rheumatic, as exemplified below in an 8-year-old girl, hailing from Uganda, who was diagnosed and managed as rheumatic MR with unusually elevated and persistent systemic inflammatory state with chronic renal dysfunction disproportionate to her cardiac status. Further workup led towards the possibility of early onset systemic lupus erythematosus (SLE). The valvular involvement in SLE closely resembles rheumatic heart disease (RHD). A high level of clinical suspicion is essential for diagnosing childhood-onset SLE. Coexistence of RHD and SLE is extremely rare and has significant implications for management.
ISSN:1467-1107
DOI:10.1017/S1047951125101248