Unexpected 20-membered macrocycles obtained by the condensation of α,α-dihalo-β-oxoaldehydes with diaminofurazan
Herein, we have isolated new 20-membered macrocycles by the simple condensation of α,α-dihalo-β-oxoaldehydes with diaminofurazan in acetonitrile. The interior and exterior sites of these macrocycles comprise hydrogen and halogen bond donor sites, respectively. Depending on the electron donating or a...
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Published in | New journal of chemistry Vol. 48; no. 29; pp. 12869 - 12872 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
22.07.2024
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | Herein, we have isolated new 20-membered macrocycles by the simple condensation of α,α-dihalo-β-oxoaldehydes with diaminofurazan in acetonitrile. The interior and exterior sites of these macrocycles comprise hydrogen and halogen bond donor sites, respectively. Depending on the electron donating or accepting character of the substituents at the exterior sites of macrocyclic scaffolds, the average cavity diameters range from 8.15 to 8.47 Å.
Reaction of α,α-dihalo-β-oxoaldehydes with diaminofurazan in acetonitrile affords unexpected 20-membered macrocycles. |
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Bibliography: | For ESI and crystallographic data in CIF or other electronic format see DOI Electronic supplementary information (ESI) available: Experimental procedures, analytical data and spectra. CCDC https://doi.org/10.1039/d4nj01789g 2338045-2338047 |
ISSN: | 1144-0546 1369-9261 |
DOI: | 10.1039/d4nj01789g |