Copper(ii)-catalyzed three-component coupling sequence for the efficient synthesis of 2-arylquinolines: 1,4-dioxane serving as the C2 building block

[Display omitted] A copper-catalyzed three-component coupling sequence for 2-arylquinolines formation from aromatic aldehydes, anilines and 1,4-dioxane has been described. Unexpectedly, 1,4-dioxane served as a C2 building block in this transformation. This formal [4 + 2] approach provides rapid acce...

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Bibliographic Details
Published inMendeleev communications Vol. 34; no. 3; pp. 401 - 403
Main Authors Zhang, Yong, Bai, Junxue, Sun, Song
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2024
Subjects
1,4-dioxane
C2 building block
copper catalysis
cycloaddition
quinolines
three-component coupling reaction
copper catalysis
three-component coupling reaction
C2 building block
cycloaddition
quinolines
1,4-dioxane
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Summary:[Display omitted] A copper-catalyzed three-component coupling sequence for 2-arylquinolines formation from aromatic aldehydes, anilines and 1,4-dioxane has been described. Unexpectedly, 1,4-dioxane served as a C2 building block in this transformation. This formal [4 + 2] approach provides rapid access to 2-arylquinolines with broad substrate scope under mild conditions.
ISSN:0959-9436
DOI:10.1016/j.mencom.2024.04.028