Effect of oseltamivir and oligoelements on the levels of 5-hiaa and calcium in brain of young rats

• Published in: Biomedicine & aging pathology Vol. 1; no. 3; pp. 193 - 195
• Main Authors: Guzmán, David Calderón, García, Ernestina Hernández, Mejía, Gerardo Barragán, Olguín, Hugo Juárez, Ángel, Daniel Santamaría del
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.07.2011
• Subjects: Brain damage; Calcium; Nutrients; Rat; Serotonine; Brain damage; Nutrients; Calcium; Rat; Serotonine
• ISSN: 2210-5220; 2210-5220
• DOI: 10.1016/j.biomag.2011.09.006

Oseltamivir is a neuraminidase inhibitor effective for treating both seasonal flu and H5N1 influenza A virus infections. However, its effect on 5-HIAA and calcium in very young models remains unclear. The purpose of this study was to determine the effect of oseltamivir on 5-HIAA and calcium of young rats’ brain in presence of oligoelements. Male Wistar rats (weight 80 g) were treated as follows: group I NaCl 0.9% (as control); group II oseltamivir (50 mg/kg); group III oligoelements (50 μL/rat); and group IV oseltamivir (50 mg/kg) + oligoelements (50 μL/rat), all doses were administered intraperitoneally daily for three days. The brain of animals was obtained to measure levels of 5-HIAA, calcium and H 2O 2 through validated methods. 5-HIAA levels decreased partially in groups treated with oseltamivir and oligoelements, but calcium and H 2O 2 increased in those animals. The results of this study suggest that the intake of oseltamivir and oligoelements do not induce changes in the serotonergic and calcium metabolism and protect the young rats’ brain of H 2O 2 damage.