The effects of treatment, clinical and demographic factors on recovery of orientation after ECT: A care network study

• Published in: Journal of affective disorders Vol. 368; pp. 337 - 342
• Main Authors: Barreiros, Ana Rita, Massaneda-Tuneu, Clara, Waite, Susan, Sarma, Shanthi, Branjerdporn, Grace, Zeng, Celeste, Dong, Vanessa, Loo, Colleen, Martin, Donel M.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2025
• Subjects: Electroconvulsive therapy; Predictors; Retrograde amnesia; Time to reorientation; Electroconvulsive therapy; Retrograde amnesia; Time to reorientation; Predictors
• ISSN: 0165-0327; 1573-2517; 1573-2517
• DOI: 10.1016/j.jad.2024.09.097

Time to reorientation after electroconvulsive therapy (ECT) has been shown to predict retrograde amnesia and is a useful measure for monitoring patients over the acute treatment course. This study investigated the effects of treatment, clinical and demographic factors on the recovery of orientation after ECT. Data from 555 ECT patients across two different clinical CARE Network sites were analysed. The main outcome variable was recovery of orientation on the 10-Item Orientation Questionnaire assessed after every ECT treatment. A linear mixed-effects repeated measures model was used to predict the recovery of orientation across the ECT course based on multiple factors, including age, gender, electrode montage, ECT number and frequency, diagnosis, and baseline cognitive impairment. Type of ECT demonstrated a significant effect (F(2, 2341) = 48.414, p = 0.000): individuals who received right unilateral (RUL) ultrabrief ECT or bifrontal ECT had higher orientation scores compared to those who received RUL brief pulse ECT. Older age groups and female patients had lower orientation scores. Baseline global cognitive functioning significantly influenced orientation scores (F(3, 2339) = 43.597, p = 0.000), with individuals with no or mild cognitive impairment exhibiting higher scores. The study involved a retrospective analysis of de-identified data, which may have introduced inherent biases with missing data. This large-scale retrospective, real-world study showed that recovery of orientation after ECT was most affected by ECT type, though age, gender, and baseline level cognitive impairment also affected outcomes. These findings can inform the interpretation of post ECT orientation scores, facilitating its monitoring and optimisation of patient outcomes. •RUL-UB ECT was associated with better orientation recovery.•Patients with mild/no baseline cognitive impairment had better orientation recovery.•Poorer orientation recovery occurred in older and female patients.•RUL-UB ECT produced optimal orientation recovery in older old patients.