Low to non-existent sperm content of pre-ejaculate in perfect-use contraceptive withdrawal, a pilot study

• Published in: Contraception (Stoneham) p. 110555
• Main Authors: Patel, Jasmine, Nelson, Anita L., Nguyen, Brian T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.08.2024
• Subjects: Male contraception; Men’s reproductive health; Pre-ejaculate; Sperm; Withdrawal; Male contraception; Men’s reproductive health; Sperm; Withdrawal; Pre-ejaculate
• ISSN: 0010-7824; 1879-0518; 1879-0518
• DOI: 10.1016/j.contraception.2024.110555

To assess pregnancy risk following perfect use of the withdrawal method by quantification of sperm in pre-ejaculate. We conducted a pilot study of sperm and factors linked to its presence in pre-ejaculate samples among healthy, reproductive-age, withdrawal-experienced men. Participants provided up to three paired pre-ejaculate and ejaculate specimens in 72-hour intervals. We analyzed samples for volume, consistency, sperm concentration, count, and motility. We set clinical pregnancy risk as our primary outcome, defined as sperm concentration >1million/mL. From 70 paired samples (N = 24 participants, median age: 27 years), we identified sperm in nine (12.9%) pre-ejaculate samples, from six (25.0%) participants. Only seven samples contained sperm in concentrations of significant clinical pregnancy risk. All ejaculatory specimens contained motile sperm in concentrations of significant pregnancy risk. In this study of the pre-ejaculate of perfect-use withdrawal users, motile sperm were usually absent, or found inconsistently and in insufficient quantities to confer significant clinical pregnancy risk. While correct and consistent withdrawal use is likely to be highly effective, given that motile sperm in concentrations >1 million/mL are usually absent or inconsistently present in pre-ejaculate, clinical trial data is lacking.