The prevalence of liver abnormalities in individuals with ZZ Alpha-1 Antitrypsin deficiency

Alpha-1 antitrypsin deficiency (AATD) is a hereditary disorder defined by low plasma levels of alpha-1 antitrypsin (AAT). It is linked primarily with the development of lung, liver and skin disease. The most common abnormal variant of AAT is the 'Z' variant. It is the AATD type most associ...

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Published inBMC proceedings Vol. 9; no. S1; p. A40
Main Authors McElvaney, OF, Fee, L, O’Connor, C, Carroll, TP
Format Journal Article
LanguageEnglish
Published London BioMed Central 14.01.2015
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Summary:Alpha-1 antitrypsin deficiency (AATD) is a hereditary disorder defined by low plasma levels of alpha-1 antitrypsin (AAT). It is linked primarily with the development of lung, liver and skin disease. The most common abnormal variant of AAT is the 'Z' variant. It is the AATD type most associated with the development of liver disease. The aim of this project is to determine the prevalence of liver abnormalities in ZZ AATD individuals.
ISSN:1753-6561
1753-6561
DOI:10.1186/1753-6561-9-S1-A40