Isolation and structure of rolliniastatin 1 from the South American tree Rollinia mucosa

• Published in: Canadian journal of chemistry Vol. 65; no. 6; pp. 1433 - 1435
• Main Authors: PETTIT, G. R, CRAGG, G. M, POLONSKY, J, HERALD, D. L, ANIMESH GOSWAMI, SMITH, C. R, MORETTI, C, SCHMIDT, J. M, WEISLEDER, D
• Format: Journal Article
• Language: English; French
• Published: Ottawa, ON National Research Council of Canada 01.06.1987
• Subjects: Analytical, structural and metabolic biochemistry; Aromatic and heterocyclic compounds; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Heterocyclic compounds, pigments; Other biological molecules; Antineoplastic agent; Vegetals; Molecular structure; Dicotyledones; Angiospermae; Spermatophyta; NMR spectrometry; Annonaceae; X ray diffraction

Rolliniamucosa (Annonaceae), known in primitive medical practices of Indonesia and the West Indies as a treatment for tumors, has been investigated employing the seeds from a South American variety and the murine P388 lymphocytic leukemia (PS) for bioassay. The principal antineoplastic constituent (...