Isolation and structure of rolliniastatin 1 from the South American tree Rollinia mucosa

• Published in: Canadian journal of chemistry Vol. 65; no. 6; pp. 1433 - 1435
• Main Authors: PETTIT, G. R, CRAGG, G. M, POLONSKY, J, HERALD, D. L, ANIMESH GOSWAMI, SMITH, C. R, MORETTI, C, SCHMIDT, J. M, WEISLEDER, D
• Format: Journal Article
• Language: English; French
• Published: Ottawa, ON National Research Council of Canada 01.06.1987
• Subjects: Analytical, structural and metabolic biochemistry; Aromatic and heterocyclic compounds; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Heterocyclic compounds, pigments; Other biological molecules; Antineoplastic agent; Vegetals; Molecular structure; Dicotyledones; Angiospermae; Spermatophyta; NMR spectrometry; Annonaceae; X ray diffraction
• ISSN: 0008-4042; 1480-3291
• DOI: 10.1139/v87-242

Rolliniamucosa (Annonaceae), known in primitive medical practices of Indonesia and the West Indies as a treatment for tumors, has been investigated employing the seeds from a South American variety and the murine P388 lymphocytic leukemia (PS) for bioassay. The principal antineoplastic constituent (PS, 28% life extension, at 0.25 mg/kg and ED 50 4.5 × 10 −5  μg/mL) was found to be a new bis-tetrahydrofuran designated rolliniastatin 1. Structural elucidation of rolliniastatin 1 was accomplished by a combination of high resolution nuclear magnetic resonance (300 MHz), mass spectral, and X-ray crystal structure techniques.