Comparison of two types of sorbents for solid-phase extraction of cannabimimetic MDMB(N)-073F metabolites from urine

The purpose of this work is to study the possibility of using cartridges with a mixed sorbent C8/SAX for the extraction of synthetic cannabimimetic metabolites MDMB (N)-073F from urine. It was used enzymatic hydrolysis of urine, solid phase extraction using cartridges C8/SAX and C8/SCX with mixed ph...

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Bibliographic Details
Published inSudebno-meditsinskaia ekspertiza Vol. 64; no. 1; p. 29
Main Authors Kataev, S S, Dvorskaya, O N, Gofenberg, M A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2021
Subjects
Gas Chromatography-Mass Spectrometry
Mass Spectrometry
Solid Phase Extraction
MDMB (N) -073F
synthetic cannabimimetics
solid phase extraction
gas chromatography — mass spectrometry
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Summary:The purpose of this work is to study the possibility of using cartridges with a mixed sorbent C8/SAX for the extraction of synthetic cannabimimetic metabolites MDMB (N)-073F from urine. It was used enzymatic hydrolysis of urine, solid phase extraction using cartridges C8/SAX and C8/SCX with mixed phase, derivatization and gas chromatography with a mass spectrometric detector. The results of the study allow us to recommend cartridges for solid-phase extraction with an anion-exchange phase (C8/SAX or SAX) when conducting a targeted study for the presence of cannabimimetics metabolites that have compounds with a carboxyl group as the main metabolites.
ISSN:0039-4521
DOI:10.17116/sudmed20216401129