Silver impregnated nanoparticles of titanium dioxide as carriers for 211 At
Abstract The 211 At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of 211 At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes 211 At bioconjugates unstable in ph...
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Published in | Radiochimica acta Vol. 104; no. 4; pp. 267 - 275 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
28.04.2016
|
Online Access | Get full text |
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Summary: | Abstract
The
211
At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately
use of
211
At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules
which makes
211
At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of
211
At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for
211
At. Ag
+
cations have been absorbed on the nanometer-sized TiO
2
particles (15 and 32 nm)
through ion exchange process and were reduced in Tollens' reaction. The obtained TiO
2
-Ag nanoparticles were labeled with
211
At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing
conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS
buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make
TiO
2
/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling
agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the
TiO
2
/Ag surface. |
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ISSN: | 0033-8230 2193-3405 |
DOI: | 10.1515/ract-2014-2373 |