Features of acute megakaryoblastic leukemia diagnosis in a child with Down syndrome

We present a description of the difficulties in diagnosing acute megakaryoblastic leukemia in a child with Down syndrome aggravated by multiple comorbidities. In this case, a comprehensive assessment of clinical data, the results of an automatic complete blood count with a detailed interpretation of...

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Bibliographic Details
Published inOnkogematologii͡a Vol. 18; no. 1; pp. 31 - 38
Main Authors Guskova, N. K., Selyutina, O. N., Lysenko, I. B., Kozel, Yu. Yu, Kozyuk, O. V., Dmitrieva, V. V., Baranenkova, M. A., Nozdricheva, A. S.
Format Journal Article
LanguageEnglish
Russian
Published ABV-press 14.03.2023
Subjects
acute megakaryoblastic leukemia
acute myeloid leukemia
down syndrome
flow cytometry
morphological examination of the bone marrow
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Summary:We present a description of the difficulties in diagnosing acute megakaryoblastic leukemia in a child with Down syndrome aggravated by multiple comorbidities. In this case, a comprehensive assessment of clinical data, the results of an automatic complete blood count with a detailed interpretation of the entire range of parameters, as well as morphological and immunophenotypic bone marrow examination using an extended panel of monoclonal antibodies played a key role in the diagnosis.
ISSN:1818-8346
2413-4023
DOI:10.17650/1818-8346-2023-18-1-31-38