σ-Complexes as biophysical and biochemical probes. Part II. Transformations of σ-complex intermediates from reaction of 4-nitrobenzofuroxan and methoxide ion

Reaction of 4-nitrobenzofuroxan with methoxide ion in methanolic dimethyl sulphoxide solution gives rise to 7-hydroxy-4-nitrobenzofurazan (as the anion) and 7-methoxy-4-nitrobenzofurazan (as the methoxide C-7 adduct); the proposed reaction mechanism invokes the formation of several transient interme...

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Bibliographic Details
Published inCanadian journal of chemistry Vol. 55; no. 15; pp. 2852 - 2855
Main Authors Buncel, Erwin, Chuaqui-Offermanns, Noemi, Hunter, Brian K, Norris, Albert R
Format Journal Article
LanguageEnglish
Published Ottawa, Canada NRC Research Press 01.08.1977
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Summary:Reaction of 4-nitrobenzofuroxan with methoxide ion in methanolic dimethyl sulphoxide solution gives rise to 7-hydroxy-4-nitrobenzofurazan (as the anion) and 7-methoxy-4-nitrobenzofurazan (as the methoxide C-7 adduct); the proposed reaction mechanism invokes the formation of several transient intermediates. The results bear on the postulated mechanism for the antileukemic activity of 4-nitrobenzofuroxan.
ISSN:0008-4042
1480-3291
DOI:10.1139/v77-396