Absorbance Correction H-Point Standard Addition Method for Simultaneous Spectrophotometric Determination of Ramipril, Hydrochlorothiazide and Telmisartan in Tablets

• Published in: Asian Journal of Research in Chemistry Vol. 8; no. 2; p. 69
• Main Authors: Sivasubramanian, Lakshmi, Lakshmi, K.S.
• Format: Journal Article
• Language: English
• Published: Raipur A&V Publications 01.02.2015
• ISSN: 0974-4169; 0974-4150
• DOI: 10.5958/0974-4150.2015.00014.0

Simultaneous spectrophotometric method described for the determination of Ramipril, Hydrochlorothiazide and Telmisartan in tablets using absorbance correction -- H-Point Standard addition method (HPSAM). A simple and novel method absorbance correction -- HPSAM is reported for simultaneous estimation of three drugs using UV-visible spectrophotometry without any prior separation of samples. The linear range was 0.8-3 μg/mL for Ramipril, Hydrocholrothiazide and Telmisartan. The relative standard deviation for the simultaneous determination of 2 μg/mL of Ramipril, hydrochlorothiazide and Telmisartan by applying HPSAM was 0.373, 1.176 and 1.296, respectively. The reported methods HPSAM can be claimed as green analytical chemistry, as it does not involve the use of organic solvents and hence can be utilized for the routine analysis of these drugs from tablets.