Prospects for the application of inhibitors of carbonic anhydrase isoforms IX and XII in oncology

Human carbonic anhydrase isoforms IX and XII play a key role in maintaining acid-base balance in solid tumors, creating a favorable microenvironment for the growth, invasion and metastasis of tumor cells. In the last few years, a number of scientific groups have published results that inhibition of...

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Published inUchenye zapiski (Sankt-Peterburgskiĭ gosudarstvennyĭ medit͡s︡inskiĭ universitet im. akad. I.P. Pavlova) Vol. 30; no. 3; pp. 22 - 35
Main Authors Kalinin, S. А., Sharonova, Т. V., Malkova, А. М., Ageev, S. V., Semenov, К. N., Sharoyko, V. V.
Format Journal Article
LanguageEnglish
Russian
Published Academician I.P. Pavlov First St. Petersburg State Medical University 01.04.2024
Subjects
carbonic anhydrase inhibitors
oncological diseases
sulfonamides
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Summary:Human carbonic anhydrase isoforms IX and XII play a key role in maintaining acid-base balance in solid tumors, creating a favorable microenvironment for the growth, invasion and metastasis of tumor cells. In the last few years, a number of scientific groups have published results that inhibition of isoforms IX and XII significantly increases the effectiveness of classical chemotherapy, makes it possible to suppress the resistance of tumor cells to chemotherapy and increase their sensitivity to the used drugs (including reducing the dose of cytostatics). In the review, we analyzed the scientific literature on the role of carbonic anhydrase isoforms IX and XII in carcinogenesis and on the combined effect of carbonic anhydrase inhibitors with antitumor drugs.
ISSN:1607-4181
2541-8807
DOI:10.24884/1607-4181-2023-30-3-22-35