THREE-DIMENSIONAL ECHOGRAPHIC EVALUATION OF CHORION VASCULARIZATION IN 1st TRIMESTER OF GESTATION IN WOMEN WITN THROMBOFILIA

• Published in: Kubanskiĭ nauchnyĭ medit︠s︡inskiĭ vestnik Vol. 25; no. 6; pp. 19 - 25
• Main Authors: Asriyants, M. A., Astafieva, O. V., Shcherbina, V. G.
• Format: Journal Article
• Language: English; Russian
• Published: Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” 21.12.2018
• Subjects: 3d reconstruction; miscarriage; thrombophilia; trophoblast; vocal
• ISSN: 1608-6228; 2541-9544
• DOI: 10.25207/1608-6228-2018-25-6-19-25

Aim. Determine the threshold values of quantitative indices of chorionic volume flow in pregnant women with thrombophilia in the first trimester of pregnancy for the prediction of miscarriage and evaluate the effectiveness of anticoagulant therapy. Materials and methods. Ultrasound examination of the embryo and extraembryonic structures with volume reconstruction of the chorion and determination of quantitative indices using VOCAL program − vascularization index (VI), flow index (FI), vascularization flow index (VFI) in women with thrombophilia from 7th to 10th of the week of gestation. Results. The analysis of the quantitative parameters VI, FI and VFI in pregnant women in the first trimester showed high reliability (p<0.001) in the value of VI and VFI in pregnant women with thrombophilia without treatment and in the pregnant control group, as well as in pregnant women with thrombophilia before and after anticoagulant therapy. Among the most informative parameters for assessing the chorion vascularization in predicting miscarriage VFI≤7,80 has highest value for negative outcome. Index VI due to the very high specificity (SP = 82.6%) better more informative for predicting a favorable outcome. Conclusion. The use of the proposed method allows us to identify a risk group for predicting miscarriage in the first trimester in pregnant women with thrombophilia and promptly prescribe anticoagulant therapy and evaluate its efficiency.