Personalized therapy with bacteriophages of digestive diseases

• Published in: Zhurnal infektologii Vol. 14; no. 2; pp. 47 - 54
• Main Authors: Gonchar, N. V., Ermolenko, K. D., Skripchenko, N. V.
• Format: Journal Article
• Language: English; Russian
• Published: Journal Infectology 13.07.2022
• Subjects: bacteriophage gut virus; bacteriophages; digestive diseases; gut microbiota; therapy
• ISSN: 2072-6732
• DOI: 10.22625/2072-6732-2022-14-2-47-54

Current insights into the close relationship between human health and the gut microbiota, as well as recent advances in molecular biology suggesting a significant role for gut viromas, have encouraged research into the therapeutic usefulness of bacteriophages. The purpose of this review is to consider the prospects for the use of bacteriophages for the correction of the gut microbiota and therapy of digestive system diseases. The review describes the basics of phage biology, peculiarities of bacteriophage virome of the intestine in gastroenterological pathology; it highlights modern methods of phage-based therapy and prevention, considers problems of phage therapy and ways to overcome them. It is shown that the use of phages can become a key personalized approach to the treatment and prevention of infectious and non-infectious gastroenterological diseases.