Prolonged course of novel coronavirus infection COVID-19 with the formation of pulmonary fibrosis in an HIV-infected patient

A description of a clinical case of a severe, protracted course of coronavirus infection (COVID-19) in a patient with advanced stage HIV infection, characterized by prolonged release of the SARS-CoV-2 virus and the formation of pulmonary fibrosis against the background of an active viral infection,...

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Bibliographic Details
Published inZhurnal infektologii Vol. 16; no. 1; pp. 87 - 93
Main Authors Savchenko, M. A., Musatov, V. B., Gusev, D. A., Cinzerling, V. A.
Format Journal Article
LanguageEnglish
Russian
Published Journal Infectology 09.04.2024
Subjects
coronavirus infection covid-19
hiv
morphological picture
pneumofibrosis
pulmonary fibrosis
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Summary:A description of a clinical case of a severe, protracted course of coronavirus infection (COVID-19) in a patient with advanced stage HIV infection, characterized by prolonged release of the SARS-CoV-2 virus and the formation of pulmonary fibrosis against the background of an active viral infection, is presented. COVID-19 infection occurred in an immunosuppressed patient without ART. During the period of inpatient treatment, a comprehensive examination was carried out to exclude HIV-associated lung lesions; no evidence of viral, fungal, or bacterial pathology was obtained; mycobacterial infections were also excluded. Despite two courses of antiviral therapy, the use of anti-Covid plasma and complex pathogenetic therapy, persistence of SARS-CoV-2 replication was observed for eight months, with a steady progression of the disease, ending in death.
ISSN:2072-6732
DOI:10.22625/2072-6732-2024-16-1-87-93