Stress protection method for surgical treatment of patients with head and neck cancer

• Published in: Opukholi golovy i shei Vol. 13; no. 3; pp. 24 - 31
• Main Authors: Vasiliev, D. N., Kulbakin, D. E., Choynzonov, E. L., Avdeev, S. V., Azovskaya, D. Yu, Lee, A. A., Khavkin, N. M.
• Format: Journal Article
• Language: English; Russian
• Published: ABV-press 11.12.2023
• Subjects: dalargin; immunity; multimodal anesthesia; organoprotection; perioperative period; stress protection
• ISSN: 2222-1468; 2411-4634
• DOI: 10.17650/2222-1468-2023-13-3-24-31

Introduction. The surgical stage of treatment is the most important component of the combined method of treatment in cancer patients. However, it is associated with the development of a number of complications caused by stress. In this regard, the modern concept of an anesthesiological manual should also be aimed at protecting the body from surgical stress, which requires the search and development of new gentle methods of anesthesia. Aim. To provide an overview of modern stress protection methods in anesthesia and consider the role of dalargin with carbohydrate loading as a component of stress protection in oncological surgery. Materials and methods. Using the electronic resources of the PubMed and eLibrary search engines, a literary review of 147 scientific papers over the past 30 years has been conducted, which contain an evidence-based experimental and clinical base on the use of dalargin in medical practice. Results. A systematic review of stress protection methods in anesthesiology is presented. The role of dalargin in anesthesiological practice during surgical treatment in cancer patients, including when performing delayed reconstructions, is shown. Conclusion. The use of dalargin in combination with carbohydrate loading in cancer patients is justified and requires further detailed study. The ability to stimulate endogenous opioid receptors and modulate pain perception, its organoprotective and anti-inflammatory properties, as well as a favorable safety profile make dalargin a valuable addition to the tools for anesthesia in oncology.