Hyper-eosinophilia in the asthma clinic

• Published in: Medicine (Abingdon. 1995, UK ed.) Vol. 51; no. 10; pp. 719 - 725
• Main Authors: Gates, Jessica, Dhariwal, Jaideep, Nanzer, Alexandra M
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.10.2023
• Subjects: Allergic bronchopulmonary aspergillosis; anti-neutrophil cytoplasmic antibody-associated vasculitis; asthma; eosinophilic pneumonia; hypereosinophilia; hypereosinophilic syndrome; hypereosinophilia; anti-neutrophil cytoplasmic antibody-associated vasculitis; asthma; Allergic bronchopulmonary aspergillosis; hypereosinophilic syndrome; eosinophilic pneumonia
• ISSN: 1357-3039; 1878-9390
• DOI: 10.1016/j.mpmed.2023.07.007

Hyper-eosinophilic lung diseases are a group of rare lung conditions defined by airway or tissue eosinophilia and frequently associated with significant morbidity and mortality. This article sets out a diagnostic pathway for people presenting with features of eosinophilic lung disease and covers important differential diagnoses. Many eosinophilic lung diseases are responsive to corticosteroid therapy, but this is associated with significant risk and adverse effects as prolonged courses of treatment are often necessary. In recent years, there have been significant advances in the therapeutic options for people with eosinophilic lung disease with the advent of monoclonal antibodies targeting eosinophils and their pathways.