Structural and immunological characterization of a Pen a 1 mutant, carrying amino acid substitutions in all major IgE-binding sites

RATIONALE: Since Pen a 1 (tropomyosin), the only major allergen of the brown shrimp Penaeus aztecus, is responsible for the majority of IgE-mediated hypersensitivity to shrimp, a mutated mPen a 1 was produced as a vaccine candidate for shrimp-specific immunotherapy (SIT).

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 115; no. 2; p. S204
Main Authors Reese, G., Viebranz, J., Randow, S., San-Miguel, M., Lauer, I., Lehrer, S.B., Vieths, S.
Format Journal Article
LanguageEnglish
Published St. Louis Mosby, Inc 01.02.2005
Elsevier Limited
Subjects
Allergies
Amino acids
Mutation
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Summary:RATIONALE: Since Pen a 1 (tropomyosin), the only major allergen of the brown shrimp Penaeus aztecus, is responsible for the majority of IgE-mediated hypersensitivity to shrimp, a mutated mPen a 1 was produced as a vaccine candidate for shrimp-specific immunotherapy (SIT).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2004.12.829