Peptidomic characterization of hemorrhagic shock plasma samples: Effects of tranexamic acid

Previous studies enlighten the fundamental role of the intestine in shock: according to the so called “Autodigestion hypothesis” the intestinal mucosal barrier, damaged by hypoperfusion, allows digestive enzymes, proteases and lipases to escape the lumen and reach the systemic circulation leading to...

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Published inJournal of critical care Vol. 42; p. 380
Main Authors Maffioli, E., Aletti, F., Grassi Scalvini, F., Nonnis, S., Santagata, F., Morelli, S., Kistler, E.B., Schmid-Schoenbein, G.W., Negri, A., Tedeschi, G.
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier Inc 01.12.2017
Elsevier Limited
Subjects
Acids
Antifibrinolytic agents
Critical care
Hemorrhage
Hypotheses
Peptides
Plasma
Protease inhibitors
Proteases
Rodents
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Summary:Previous studies enlighten the fundamental role of the intestine in shock: according to the so called “Autodigestion hypothesis” the intestinal mucosal barrier, damaged by hypoperfusion, allows digestive enzymes, proteases and lipases to escape the lumen and reach the systemic circulation leading to a strong inflammatory reaction and multi-organ dysfunction.[...]the resulting increased proteolytic activity causes the cleavage of several membrane receptors on the endothelial cells with consequent loss of cellular functions.A label-free quantitative proteomic investigation, conducted in our laboratory, demonstrated for the first time that plasma displays an increase in peptides possibly generated by serine proteases after hemorrhagic shock, linking proteases to the larger presence of circulating peptides [1].
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2017.09.027