Consistent composition and potency of freeze dried tablets for sublingual immunotherapy

Release kinetics of individual allergen components from source materials differ, and the production process must be optimised individually for every source material in order to secure consistent composition and potency of the final drug product. Methods Aqueous extraction of grass and ragweed pollen...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 141; no. 2; p. AB171
Main Authors Henmar, Helene, Sønderkær, Susanne, Nørby, Pernille H., Christensen, Lars H., Larsen, Jorgen N.
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2018
Elsevier Limited
Subjects
Freeze drying
Immunotherapy
Oral administration
Tablets
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Summary:Release kinetics of individual allergen components from source materials differ, and the production process must be optimised individually for every source material in order to secure consistent composition and potency of the final drug product. Methods Aqueous extraction of grass and ragweed pollen as well as house dust mite (HDM) particles was performed under chemical conditions resembling the conditions on the airway mucosa.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.545