GW28-e0736 Digoxin-induced Anemia among Patients with Atrial Fibrillation and Heart Failure: Clinical Data Analysis and Drug-gene Interaction Network
Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14-1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33-1.59-, P =4.27x10-5). Func...
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| Published in | Journal of the American College of Cardiology Vol. 70; no. 16; pp. C26 - C27 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Elsevier Inc
17.10.2017
Elsevier Limited |
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| Abstract | Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14-1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33-1.59-, P =4.27x10-5). Functional analysis indicated that these genes were significantly enriched in the biological processes of iron transport, which are closely related to iron deficiency anemia. |
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| AbstractList | Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14-1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33-1.59-, P =4.27x10-5). Functional analysis indicated that these genes were significantly enriched in the biological processes of iron transport, which are closely related to iron deficiency anemia. |
| Author | Xu, Zhe Lin, Yubi Feng, Ruiling Zhang, Qianhuan He, Siqi Huang, Zifeng Wang, Kejian Liu, Yang Zhang, Bin Wu, Shulin Chen, Wanqun Xue, Yumei |
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| SubjectTerms | Anemia Beta blockers Cardiac arrhythmia Cardiology Data analysis Data processing Digoxin Fibrillation Heart Heart diseases Heart failure Iron deficiency |
| Title | GW28-e0736 Digoxin-induced Anemia among Patients with Atrial Fibrillation and Heart Failure: Clinical Data Analysis and Drug-gene Interaction Network |
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