GW28-e0736 Digoxin-induced Anemia among Patients with Atrial Fibrillation and Heart Failure: Clinical Data Analysis and Drug-gene Interaction Network

Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14-1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33-1.59-, P =4.27x10-5). Func...

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Published inJournal of the American College of Cardiology Vol. 70; no. 16; pp. C26 - C27
Main Authors Lin, Yubi, Xue, Yumei, He, Siqi, Feng, Ruiling, Xu, Zhe, Chen, Wanqun, Huang, Zifeng, Liu, Yang, Zhang, Qianhuan, Zhang, Bin, Wang, Kejian, Wu, Shulin
Format Journal Article
LanguageEnglish
Published New York Elsevier Inc 17.10.2017
Elsevier Limited
Subjects
Anemia
Beta blockers
Cardiac arrhythmia
Cardiology
Data analysis
Data processing
Digoxin
Fibrillation
Heart
Heart diseases
Heart failure
Iron deficiency
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Summary:Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14-1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33-1.59-, P =4.27x10-5). Functional analysis indicated that these genes were significantly enriched in the biological processes of iron transport, which are closely related to iron deficiency anemia.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.091