Targeting NAD+ Metabolism to Modulate Autoimmunity and Inflammation

NAD+ biology is involved in controlling redox balance, functioning as a coenzyme in numerous enzymatic reactions, and is a cofactor for Sirtuin enzymes and a substrate for multiple regulatory enzyme reactions within and outside the cell. At the same time, NAD+ levels are diminished with aging and ar...

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Published inThe Journal of immunology (1950) Vol. 212; no. 7; pp. 1043 - 1050
Main Authors Wu, Jing, Han, Kim, Sack, Michael N
Format Journal Article
LanguageEnglish
Published United States 01.04.2024
Subjects
Animals
Autoimmune Diseases
Autoimmunity
Humans
Inflammation
Mice
NAD - metabolism
Oxidation-Reduction
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Summary:NAD+ biology is involved in controlling redox balance, functioning as a coenzyme in numerous enzymatic reactions, and is a cofactor for Sirtuin enzymes and a substrate for multiple regulatory enzyme reactions within and outside the cell. At the same time, NAD+ levels are diminished with aging and are consumed during the development of inflammatory and autoimmune diseases linked to aberrant immune activation. Direct NAD+ augmentation via the NAD+ salvage and Priess-Handler pathways is being investigated as a putative therapeutic intervention to improve the healthspan in inflammation-linked diseases. In this review, we survey NAD+ biology and its pivotal roles in the regulation of immunity and inflammation. Furthermore, we discuss emerging studies evaluate NAD+ boosting in murine models and in human diseases, and we highlight areas of research that remain unresolved in understanding the mechanisms of action of these nutritional supplementation strategies.
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.2300693